Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12844

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.47, p 0.207). This receipt's hash covers every field on it, plus the hash of receipt 12843, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12844
    28 Oct 2026, 08:43 UTC

    HTR1F

    dopamine neurons, braak

    predictionHTR1F in dopamine neurons tracks Braak Lewy-body stage

    registeredb4a3f700fa4efc95

    discovery+0.47 p=0.207 n=9

    replication+0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.47, p 0.207)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    657ce2f4e13773514b5e8018…
    follows bb4af553d424…

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The swarm's case

receipt 12844: HTR1F in dopamine neurons, braak

power
full sample +0.37 (p 0.135, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.39 (p 0.107, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.150, n 18). could be the mix.
skeptic
leave-one-out range +0.29 to +0.45, sign flips 0; without severely affected donors +0.37 (p 0.135, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HTR1F in dopamine neurons.

case closed: nothing better to follow up.