Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12785

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.58, p 0.102). This receipt's hash covers every field on it, plus the hash of receipt 12784, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12785
    28 Oct 2026, 07:20 UTC

    PAX8

    dopamine neurons, braak

    predictionPAX8 in dopamine neurons tracks Braak Lewy-body stage

    registered5e61e3b27a4bf728

    discovery-0.58 p=0.102 n=9

    replication+0.18 p=0.639 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.58, p 0.102)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    63406408e544280b67f52900…
    follows 6d4eafb4524c…

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The swarm's case

receipt 12785: PAX8 in dopamine neurons, braak

power
full sample -0.18 (p 0.465, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.16 (p 0.538, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.355, n 18). could be the mix.
skeptic
leave-one-out range -0.32 to -0.08, sign flips 0; without severely affected donors -0.18 (p 0.465, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PAX8 in dopamine neurons.

case closed: nothing better to follow up.