Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12732

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.47, p 0.197). This receipt's hash covers every field on it, plus the hash of receipt 12731, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12732
    28 Oct 2026, 06:10 UTC

    FLRT3

    dopamine neurons, braak

    predictionFLRT3 in dopamine neurons tracks Braak Lewy-body stage

    registered7185db08328d282d

    discovery+0.47 p=0.197 n=9

    replication-0.22 p=0.563 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.47, p 0.197)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ffc4728692e9efe5b94e89b1…
    follows db0407211917…

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The swarm's case

receipt 12732: FLRT3 in dopamine neurons, braak

power
full sample +0.29 (p 0.250, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.30 (p 0.232, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.408, n 18). could be the mix.
skeptic
leave-one-out range +0.18 to +0.42, sign flips 0; without severely affected donors +0.29 (p 0.250, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FLRT3 in dopamine neurons.

case closed: nothing better to follow up.