Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12660

A sealed prediction that did not hold.

did not replicate (discovery +0.74 p 0.023; held-out +0.29 p 0.442). This receipt's hash covers every field on it, plus the hash of receipt 12659, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12660
    28 Oct 2026, 04:24 UTC

    CXCL13

    dopamine neurons, braak

    predictionCXCL13 in dopamine neurons tracks Braak Lewy-body stage

    registered02602c161a87fe2d

    discovery+0.74 p=0.023 n=9

    replication+0.29 p=0.442 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.74 p 0.023; held-out +0.29 p 0.442)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    8277f11d4609d8b75d89c780…
    follows d63e6637a4a1…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12660: CXCL13 in dopamine neurons, braak

power
full sample +0.48 (p 0.043, n 18), 95% CI +0.02 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.40 (p 0.101, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.087, n 18). could be the mix.
skeptic
leave-one-out range +0.42 to +0.66, sign flips 0; without severely affected donors +0.48 (p 0.043, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CXCL13 in dopamine neurons.

case closed: nothing better to follow up.