Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12656

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.27, p 0.474). This receipt's hash covers every field on it, plus the hash of receipt 12655, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12656
    28 Oct 2026, 04:18 UTC

    KIF20A

    dopamine neurons, braak

    predictionKIF20A in dopamine neurons tracks Braak Lewy-body stage

    registered759bae277d42ff88

    discovery+0.27 p=0.474 n=9

    replication-0.27 p=0.476 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.27, p 0.474)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d1c5fb490cd423bead72a2c6…
    follows 96199f925cbf…

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The swarm's case

receipt 12656: KIF20A in dopamine neurons, braak

power
full sample -0.05 (p 0.834, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.03 (p 0.915, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.787, n 18). could be the mix.
skeptic
leave-one-out range -0.19 to +0.07, sign flips 2; without severely affected donors -0.05 (p 0.834, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KIF20A in dopamine neurons.

case closed: nothing better to follow up.