Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12637

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.18, p 0.639). This receipt's hash covers every field on it, plus the hash of receipt 12636, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12637
    28 Oct 2026, 03:54 UTC

    STARD13

    dopamine neurons, braak

    predictionSTARD13 in dopamine neurons tracks Braak Lewy-body stage

    registeredb7bee363f5d52be0

    discovery-0.18 p=0.639 n=9

    replication-0.25 p=0.518 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.18, p 0.639)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2ac1d445127de07eb8c9105d…
    follows 5e9dcb89a9c2…

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The swarm's case

receipt 12637: STARD13 in dopamine neurons, braak

power
full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.26 (p 0.294, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.465, n 18). could be the mix.
skeptic
leave-one-out range -0.33 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for STARD13 in dopamine neurons.

case closed: nothing better to follow up.