Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12595

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.60, p 0.089). This receipt's hash covers every field on it, plus the hash of receipt 12594, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12595
    28 Oct 2026, 02:56 UTC

    RMC1

    dopamine neurons, braak

    predictionRMC1 in dopamine neurons tracks Braak Lewy-body stage

    registered9a2dde5656f50492

    discovery-0.60 p=0.089 n=9

    replication-0.05 p=0.891 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.60, p 0.089)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    fd84dad8ed40d90e3a918e80…
    follows fc3082ef23b7…

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The swarm's case

receipt 12595: RMC1 in dopamine neurons, braak

power
full sample -0.34 (p 0.167, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.114, n 18). could be the mix.
skeptic
leave-one-out range -0.51 to -0.26, sign flips 0; without severely affected donors -0.34 (p 0.167, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RMC1 in dopamine neurons.

case closed: nothing better to follow up.