Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12523

A sealed prediction that did not hold.

HES5 is not measured in dopamine neurons. This receipt's hash covers every field on it, plus the hash of receipt 12522, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12523
    28 Oct 2026, 02:03 UTC

    HES5

    dopamine neurons, braak

    predictionHES5 in dopamine neurons tracks Braak Lewy-body stage

    registered020a2e3b164fa477

    discoveryn/a

    replicationn/a

    neededp < 0.05 twice, same sign

    HES5 is not measured in dopamine neurons

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NOT TESTED

    52956bd33db27b544d0540d7…
    follows e71b792ed9c6…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12523: HES5 in dopamine neurons, braak

cell type
HES5 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HES5 in dopamine neurons.

case closed: nothing better to follow up.