Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12472

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.09, p 0.815). This receipt's hash covers every field on it, plus the hash of receipt 12471, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12472
    28 Oct 2026, 01:00 UTC

    UBE2QL1

    dopamine neurons, braak

    predictionUBE2QL1 in dopamine neurons tracks Braak Lewy-body stage

    registered2f6a63c3a00ab8f2

    discovery+0.09 p=0.815 n=9

    replication-0.03 p=0.944 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.09, p 0.815)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d3b79a07e940d4488a96e210…
    follows 4a2f79cb0538…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12472: UBE2QL1 in dopamine neurons, braak

power
full sample -0.02 (p 0.935, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.02 (p 0.935, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
skeptic
leave-one-out range -0.18 to +0.08, sign flips 7; without severely affected donors -0.02 (p 0.935, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for UBE2QL1 in dopamine neurons.

case closed: nothing better to follow up.