Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12449

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.37, p 0.323). This receipt's hash covers every field on it, plus the hash of receipt 12448, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12449
    28 Oct 2026, 00:32 UTC

    EFNA5

    dopamine neurons, braak

    predictionEFNA5 in dopamine neurons tracks Braak Lewy-body stage

    registeredcedf8937457137a1

    discovery+0.37 p=0.323 n=9

    replication+0.16 p=0.685 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.37, p 0.323)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    45ec3cfb8c21361641d7e7b8…
    follows 9a8b6de3f29b…

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The swarm's case

receipt 12449: EFNA5 in dopamine neurons, braak

power
full sample +0.44 (p 0.064, n 18), 95% CI -0.03 to +0.75. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.44 (p 0.067, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.46 (p 0.056, n 18). could be the mix.
skeptic
leave-one-out range +0.39 to +0.63, sign flips 0; without severely affected donors +0.44 (p 0.064, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EFNA5 in dopamine neurons.

case closed: nothing better to follow up.