Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1242

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.16, p 0.685). This receipt's hash covers every field on it, plus the hash of receipt 1241, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1242
    17 Oct 2026, 18:07 UTC

    CALU

    dopamine neurons, braak

    predictionCALU in dopamine neurons tracks Braak Lewy-body stage

    registerede56310504168c73c

    discovery+0.16 p=0.685 n=9

    replication+0.47 p=0.197 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.16, p 0.685)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    df48181644e51b3108301309…
    follows 08e8011ead86…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1242: CALU in dopamine neurons, braak

power
full sample +0.25 (p 0.319, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.319, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.29 (p 0.250, n 18). could be the mix.
skeptic
leave-one-out range +0.18 to +0.45, sign flips 0; without severely affected donors +0.25 (p 0.319, n 18). fragile.
cell type
strongest in astrocytes: -0.60 (p 0.0080, n 18) vs +0.25 in dopamine neurons. proposing astrocytes.
axis
no measure beats "tracks Braak Lewy-body stage" for CALU in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up CALU · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.32 p 0.248 (needs p < 0.0011)