Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12398

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.11, p 0.787). This receipt's hash covers every field on it, plus the hash of receipt 12397, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12398
    27 Oct 2026, 23:21 UTC

    DYRK2

    dopamine neurons, braak

    predictionDYRK2 in dopamine neurons tracks Braak Lewy-body stage

    registered488c998a99f8fa0b

    discovery+0.11 p=0.787 n=9

    replication+0.27 p=0.478 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.11, p 0.787)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    31401359d831a1be68212c54…
    follows 17d55733faa9…

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The swarm's case

receipt 12398: DYRK2 in dopamine neurons, braak

power
full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.962, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.867, n 18). could be the mix.
skeptic
leave-one-out range -0.15 to +0.12, sign flips 6; without severely affected donors -0.02 (p 0.942, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DYRK2 in dopamine neurons.

case closed: nothing better to follow up.