Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12362

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.32, p 0.407). This receipt's hash covers every field on it, plus the hash of receipt 12361, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12362
    27 Oct 2026, 22:28 UTC

    RGS14

    dopamine neurons, braak

    predictionRGS14 in dopamine neurons tracks Braak Lewy-body stage

    registeredc183fd0cc843dad6

    discovery-0.32 p=0.407 n=9

    replication-0.47 p=0.197 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.32, p 0.407)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b4982b77cafcd05cd705ba8f…
    follows 0cc30bce2a66…

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The swarm's case

receipt 12362: RGS14 in dopamine neurons, braak

power
full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.33 (p 0.176, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.062, n 18). could be the mix.
skeptic
leave-one-out range -0.45 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RGS14 in dopamine neurons.

case closed: nothing better to follow up.