Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12201

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.01, p 0.982). This receipt's hash covers every field on it, plus the hash of receipt 12200, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12201
    27 Oct 2026, 18:44 UTC

    UQCRFS1

    dopamine neurons, braak

    predictionUQCRFS1 in dopamine neurons tracks Braak Lewy-body stage

    registeredeee3de9d79bb3185

    discovery+0.01 p=0.982 n=9

    replication+0.36 p=0.348 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.01, p 0.982)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f4680f7ecb1c967ec2f6301d…
    follows 36071c7e3ee7…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12201: UQCRFS1 in dopamine neurons, braak

power
full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.17 (p 0.498, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.398, n 18). could be the mix.
skeptic
leave-one-out range +0.06 to +0.30, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for UQCRFS1 in dopamine neurons.

case closed: nothing better to follow up.