Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12195

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.06, p 0.886). This receipt's hash covers every field on it, plus the hash of receipt 12194, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12195
    27 Oct 2026, 18:35 UTC

    STATH

    dopamine neurons, braak

    predictionSTATH in dopamine neurons tracks Braak Lewy-body stage

    registered71df249a5accab3e

    discovery-0.06 p=0.886 n=9

    replication+0.43 p=0.244 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.06, p 0.886)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1ebcfdae97a8b9a3491777eb…
    follows 13991f0a943c…

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The swarm's case

receipt 12195: STATH in dopamine neurons, braak

power
full sample +0.06 (p 0.800, n 18), 95% CI -0.42 to +0.52. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.814, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.774, n 18). could be the mix.
skeptic
leave-one-out range -0.04 to +0.22, sign flips 6; without severely affected donors +0.06 (p 0.800, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for STATH in dopamine neurons.

case closed: nothing better to follow up.