Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12072

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.15, p 0.702). This receipt's hash covers every field on it, plus the hash of receipt 12071, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12072
    27 Oct 2026, 15:56 UTC

    SEMA6B

    dopamine neurons, braak

    predictionSEMA6B in dopamine neurons tracks Braak Lewy-body stage

    registered10e351f24fd48b95

    discovery-0.15 p=0.702 n=9

    replication-0.54 p=0.135 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.15, p 0.702)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    100c30183afed6dcd586526f…
    follows 9d495b1c8f32…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12072: SEMA6B in dopamine neurons, braak

power
full sample -0.44 (p 0.067, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.43 (p 0.075, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.045, n 18). not the mix.
skeptic
leave-one-out range -0.58 to -0.37, sign flips 0; without severely affected donors -0.44 (p 0.067, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SEMA6B in dopamine neurons.

case closed: nothing better to follow up.