Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12048

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.17, p 0.663). This receipt's hash covers every field on it, plus the hash of receipt 12047, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12048
    27 Oct 2026, 15:25 UTC

    KCNN1

    dopamine neurons, braak

    predictionKCNN1 in dopamine neurons tracks Braak Lewy-body stage

    registered6d41cdcf7df5af5b

    discovery-0.17 p=0.663 n=9

    replication-0.29 p=0.445 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.17, p 0.663)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    aec27b00a227138928f08d0b…
    follows 3619afea158a…

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The swarm's case

receipt 12048: KCNN1 in dopamine neurons, braak

power
full sample -0.24 (p 0.337, n 18), 95% CI -0.64 to +0.26. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.24 (p 0.328, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.254, n 18). could be the mix.
skeptic
leave-one-out range -0.32 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.337, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNN1 in dopamine neurons.

case closed: nothing better to follow up.