Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12044

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.59, p 0.095). This receipt's hash covers every field on it, plus the hash of receipt 12043, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12044
    27 Oct 2026, 15:20 UTC

    ATP5PD

    dopamine neurons, braak

    predictionATP5PD in dopamine neurons tracks Braak Lewy-body stage

    registered7864fc36b760e842

    discovery+0.59 p=0.095 n=9

    replication+0.53 p=0.138 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.59, p 0.095)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    13075ce591ae07b669d8c068…
    follows b92d897a67af…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12044: ATP5PD in dopamine neurons, braak

power
full sample +0.53 (p 0.024, n 18), 95% CI +0.08 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.55 (p 0.017, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.55 (p 0.018, n 18). not the mix.
skeptic
leave-one-out range +0.46 to +0.69, sign flips 0; without severely affected donors +0.53 (p 0.024, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ATP5PD in dopamine neurons.

case closed: nothing better to follow up.