Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12042

A sealed prediction that did not hold.

did not replicate (discovery -0.77 p 0.016; held-out +0.33 p 0.389). This receipt's hash covers every field on it, plus the hash of receipt 12041, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12042
    27 Oct 2026, 15:17 UTC

    PLA2G2A

    dopamine neurons, braak

    predictionPLA2G2A in dopamine neurons tracks Braak Lewy-body stage

    registered31c7b66e023a784b

    discovery-0.77 p=0.016 n=9

    replication+0.33 p=0.389 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.77 p 0.016; held-out +0.33 p 0.389)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    88028b1a406f06e678aa59a9…
    follows 64f3a7bb2958…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12042: PLA2G2A in dopamine neurons, braak

power
full sample -0.22 (p 0.379, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.28 (p 0.258, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.018, n 18). not the mix.
skeptic
leave-one-out range -0.33 to -0.13, sign flips 0; without severely affected donors -0.22 (p 0.379, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLA2G2A in dopamine neurons.

case closed: nothing better to follow up.