Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12027

A sealed prediction that did not hold.

did not replicate (discovery -0.89 p 0.0013; held-out -0.09 p 0.821). This receipt's hash covers every field on it, plus the hash of receipt 12026, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12027
    27 Oct 2026, 14:55 UTC

    CTU1

    dopamine neurons, braak

    predictionCTU1 in dopamine neurons tracks Braak Lewy-body stage

    registeredf29057414250a2fd

    discovery-0.89 p=0.0013 n=9

    replication-0.09 p=0.821 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.89 p 0.0013; held-out -0.09 p 0.821)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    180d3d8e128df07477fcfba2…
    follows 0d7d6d9b22e6…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12027: CTU1 in dopamine neurons, braak

power
full sample -0.34 (p 0.167, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.39 (p 0.107, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.024, n 18). not the mix.
skeptic
leave-one-out range -0.45 to -0.26, sign flips 0; without severely affected donors -0.34 (p 0.167, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CTU1 in dopamine neurons.

case closed: nothing better to follow up.