Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11950

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.11, p 0.784). This receipt's hash covers every field on it, plus the hash of receipt 11949, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11950
    27 Oct 2026, 13:13 UTC

    PSMA4

    dopamine neurons, braak

    predictionPSMA4 in dopamine neurons tracks Braak Lewy-body stage

    registeredbef444ad2d502cef

    discovery+0.11 p=0.784 n=9

    replication+0.46 p=0.212 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.11, p 0.784)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4d3f845757da55b689271abd…
    follows a849bf9ef4d4…

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The swarm's case

receipt 11950: PSMA4 in dopamine neurons, braak

power
full sample +0.24 (p 0.328, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.179, n 18). could be the mix.
skeptic
leave-one-out range +0.15 to +0.37, sign flips 0; without severely affected donors +0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PSMA4 in dopamine neurons.

case closed: nothing better to follow up.