Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11877

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.34, p 0.373). This receipt's hash covers every field on it, plus the hash of receipt 11876, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11877
    27 Oct 2026, 11:36 UTC

    RPS6KA5

    dopamine neurons, braak

    predictionRPS6KA5 in dopamine neurons tracks Braak Lewy-body stage

    registered52288a65034476bf

    discovery-0.34 p=0.373 n=9

    replication+0.16 p=0.672 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.34, p 0.373)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    20a217303c9f88f0ace076a0…
    follows 1417b3177c04…

Covered by the on-chain checkpoint of receipt 11895 (2026-10-27 11:59 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11877: RPS6KA5 in dopamine neurons, braak

power
full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.11 (p 0.652, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.10 (p 0.690, n 18). could be the mix.
skeptic
leave-one-out range -0.23 to +0.01, sign flips 2; without severely affected donors -0.10 (p 0.696, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RPS6KA5 in dopamine neurons.

case closed: nothing better to follow up.