Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11865

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.648). This receipt's hash covers every field on it, plus the hash of receipt 11864, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11865
    27 Oct 2026, 11:20 UTC

    SESN3

    dopamine neurons, braak

    predictionSESN3 in dopamine neurons tracks Braak Lewy-body stage

    registered5ecf4fec4d1ee39d

    discovery+0.18 p=0.648 n=9

    replication+0.45 p=0.230 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.648)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ec59c60f11447334267bf524…
    follows 7db707fa852a…

Covered by the on-chain checkpoint of receipt 11868 (2026-10-27 11:24 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11865: SESN3 in dopamine neurons, braak

power
full sample +0.36 (p 0.142, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.34 (p 0.167, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.37 (p 0.135, n 18). could be the mix.
skeptic
leave-one-out range +0.29 to +0.53, sign flips 0; without severely affected donors +0.36 (p 0.142, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SESN3 in dopamine neurons.

case closed: nothing better to follow up.