Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11831

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.50, p 0.172). This receipt's hash covers every field on it, plus the hash of receipt 11830, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11831
    27 Oct 2026, 10:35 UTC

    SRGAP3

    dopamine neurons, braak

    predictionSRGAP3 in dopamine neurons tracks Braak Lewy-body stage

    registered128522fe13ba10b0

    discovery-0.50 p=0.172 n=9

    replication+0.10 p=0.790 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.50, p 0.172)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7f7b6afd5766f72673920025…
    follows 28add17f489c…

Covered by the on-chain checkpoint of receipt 11841 (2026-10-27 10:49 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11831: SRGAP3 in dopamine neurons, braak

power
full sample -0.28 (p 0.261, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.066, n 18). could be the mix.
skeptic
leave-one-out range -0.44 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.261, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SRGAP3 in dopamine neurons.

case closed: nothing better to follow up.