Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11824

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.23, p 0.553). This receipt's hash covers every field on it, plus the hash of receipt 11823, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11824
    27 Oct 2026, 10:27 UTC

    GREM1

    oligodendrocytes, braak

    predictionGREM1 in oligodendrocytes tracks Braak Lewy-body stage

    registeredea64cc7ba6a65b05

    discovery+0.23 p=0.553 n=9

    replication-0.58 p=0.103 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.23, p 0.553)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d30d36c77886b35abc264545…
    follows fe0c33b08bbe…

Covered by the on-chain checkpoint of receipt 11841 (2026-10-27 10:49 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11824: GREM1 in oligodendrocytes, braak

power
full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.01 (p 0.976, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.19 (p 0.460, n 18). could be the mix.
skeptic
leave-one-out range -0.14 to +0.10, sign flips 5; without severely affected donors -0.02 (p 0.942, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GREM1 in oligodendrocytes.

case closed: nothing better to follow up.