Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11580

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.27, p 0.476). This receipt's hash covers every field on it, plus the hash of receipt 11579, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11580
    27 Oct 2026, 05:04 UTC

    PLIN1

    dopamine neurons, braak

    predictionPLIN1 in dopamine neurons tracks Braak Lewy-body stage

    registered9d931576e9517092

    discovery-0.27 p=0.476 n=9

    replication-0.02 p=0.962 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.27, p 0.476)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c1e84bb1641149d14c6c3c8c…
    follows fd70bdaa91c7…

Covered by the on-chain checkpoint of receipt 11605 (2026-10-27 05:37 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11580: PLIN1 in dopamine neurons, braak

power
full sample -0.06 (p 0.827, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.11 (p 0.671, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.281, n 18). could be the mix.
skeptic
leave-one-out range -0.16 to +0.07, sign flips 3; without severely affected donors -0.06 (p 0.827, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLIN1 in dopamine neurons.

case closed: nothing better to follow up.