Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11568

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.25, p 0.520). This receipt's hash covers every field on it, plus the hash of receipt 11567, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11568
    27 Oct 2026, 04:47 UTC

    DIRAS2

    dopamine neurons, braak

    predictionDIRAS2 in dopamine neurons tracks Braak Lewy-body stage

    registered44d4081df6926e48

    discovery+0.25 p=0.520 n=9

    replication+0.30 p=0.435 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.25, p 0.520)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f82aaee48e52024a7b8d143e…
    follows 4b9b8eb1c825…

Covered by the on-chain checkpoint of receipt 11579 (2026-10-27 05:02 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11568: DIRAS2 in dopamine neurons, braak

power
full sample +0.20 (p 0.429, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.20 (p 0.429, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.935, n 18). could be the mix.
skeptic
leave-one-out range +0.12 to +0.33, sign flips 0; without severely affected donors +0.20 (p 0.429, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for DIRAS2 in dopamine neurons.

case closed: nothing better to follow up.