Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11368

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.33, p 0.386). This receipt's hash covers every field on it, plus the hash of receipt 11367, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11368
    27 Oct 2026, 00:55 UTC

    ERCC5

    microglia, braak

    predictionERCC5 in microglia tracks Braak Lewy-body stage

    registeredce40529af35e9c95

    discovery+0.33 p=0.386 n=9

    replication+0.00 p=1.000 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.33, p 0.386)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2317cfe6f612f478c45e3436…
    follows d179f0066260…

Covered by the on-chain checkpoint of receipt 11372 (2026-10-27 01:00 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11368: ERCC5 in microglia, braak

power
full sample +0.01 (p 0.969, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.08 (p 0.767, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.18 (p 0.465, n 18). could be the mix.
skeptic
leave-one-out range -0.12 to +0.10, sign flips 6; without severely affected donors +0.01 (p 0.969, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ERCC5 in microglia.

case closed: nothing better to follow up.