Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1128

A sealed prediction that did not hold.

did not replicate (discovery +0.71 p 0.031; held-out -0.21 p 0.583). This receipt's hash covers every field on it, plus the hash of receipt 1127, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1128
    17 Oct 2026, 15:08 UTC

    SH3BGRL

    dopamine neurons, braak

    predictionSH3BGRL in dopamine neurons tracks Braak Lewy-body stage

    registereda7daf38e8342eaa9

    discovery+0.71 p=0.031 n=9

    replication-0.21 p=0.583 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.71 p 0.031; held-out -0.21 p 0.583)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    9d1d2e22c9777d88c80b15c5…
    follows e58245755442…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1128: SH3BGRL in dopamine neurons, braak

power
full sample +0.18 (p 0.465, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.341, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.20 (p 0.424, n 18). could be the mix.
skeptic
leave-one-out range +0.09 to +0.36, sign flips 0; without severely affected donors +0.18 (p 0.465, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SH3BGRL in dopamine neurons.

case closed: nothing better to follow up.