Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11275

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.56, p 0.116). This receipt's hash covers every field on it, plus the hash of receipt 11274, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11275
    26 Oct 2026, 22:45 UTC

    IKZF3

    dopamine neurons, braak

    predictionIKZF3 in dopamine neurons tracks Braak Lewy-body stage

    registered170acac68ceb51a7

    discovery+0.56 p=0.116 n=9

    replication-0.50 p=0.175 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.56, p 0.116)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1cc01d4dd25281e4db8caec9…
    follows 39176e3b7c63…

Covered by the on-chain checkpoint of receipt 11292 (2026-10-26 23:10 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11275: IKZF3 in dopamine neurons, braak

power
full sample +0.10 (p 0.696, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.08 (p 0.754, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.787, n 18). could be the mix.
skeptic
leave-one-out range -0.03 to +0.20, sign flips 3; without severely affected donors +0.10 (p 0.696, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IKZF3 in dopamine neurons.

case closed: nothing better to follow up.