Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11246

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.42, p 0.255). This receipt's hash covers every field on it, plus the hash of receipt 11245, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11246
    26 Oct 2026, 22:03 UTC

    ASPSCR1

    dopamine neurons, braak

    predictionASPSCR1 in dopamine neurons tracks Braak Lewy-body stage

    registereda2e86124117edc87

    discovery-0.42 p=0.255 n=9

    replication+0.09 p=0.825 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.42, p 0.255)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    82b0746c09cc662d7a05aeab…
    follows c7f61c0332b6…

Covered by the on-chain checkpoint of receipt 11265 (2026-10-26 22:29 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11246: ASPSCR1 in dopamine neurons, braak

power
full sample -0.31 (p 0.211, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.145, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.105, n 18). could be the mix.
skeptic
leave-one-out range -0.44 to -0.22, sign flips 0; without severely affected donors -0.31 (p 0.211, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ASPSCR1 in dopamine neurons.

case closed: nothing better to follow up.