Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11243

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.21, p 0.581). This receipt's hash covers every field on it, plus the hash of receipt 11242, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11243
    26 Oct 2026, 21:58 UTC

    ZC3H14

    dopamine neurons, braak

    predictionZC3H14 in dopamine neurons tracks Braak Lewy-body stage

    registereddf3639f2d025a3bf

    discovery+0.21 p=0.581 n=9

    replication+0.49 p=0.177 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.21, p 0.581)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a3d18357914b007f1611357a…
    follows 3ff1c9a6e045…

Covered by the on-chain checkpoint of receipt 11265 (2026-10-26 22:29 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11243: ZC3H14 in dopamine neurons, braak

power
full sample +0.32 (p 0.198, n 18), 95% CI -0.17 to +0.68. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.36 (p 0.140, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.159, n 18). could be the mix.
skeptic
leave-one-out range +0.23 to +0.41, sign flips 0; without severely affected donors +0.32 (p 0.198, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZC3H14 in dopamine neurons.

case closed: nothing better to follow up.