Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11197

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.18, p 0.639). This receipt's hash covers every field on it, plus the hash of receipt 11196, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11197
    26 Oct 2026, 20:51 UTC

    ITPKC

    dopamine neurons, braak

    predictionITPKC in dopamine neurons tracks Braak Lewy-body stage

    registered7d651e040d36c97d

    discovery+0.18 p=0.639 n=9

    replication-0.80 p=0.0093 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.18, p 0.639)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1cc5d9a40581cebe548100c7…
    follows 9ca584a64c18…

Covered by the on-chain checkpoint of receipt 11209 (2026-10-26 21:09 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11197: ITPKC in dopamine neurons, braak

power
full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.35 (p 0.150, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.069, n 18). could be the mix.
skeptic
leave-one-out range -0.49 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ITPKC in dopamine neurons.

case closed: nothing better to follow up.