Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11104

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.48, p 0.190). This receipt's hash covers every field on it, plus the hash of receipt 11103, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11104
    26 Oct 2026, 18:41 UTC

    RAB17

    dopamine neurons, braak

    predictionRAB17 in dopamine neurons tracks Braak Lewy-body stage

    registeredbf3274ca62e133f3

    discovery-0.48 p=0.190 n=9

    replication-0.62 p=0.074 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.48, p 0.190)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    96b212bd062e7b9fb5b4d5d2…
    follows ffa2db88f09d…

Covered by the on-chain checkpoint of receipt 11130 (2026-10-26 19:19 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11104: RAB17 in dopamine neurons, braak

power
full sample -0.46 (p 0.054, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.46 (p 0.056, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.023, n 18). not the mix.
skeptic
leave-one-out range -0.56 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.054, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RAB17 in dopamine neurons.

case closed: nothing better to follow up.