Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11095

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.21, p 0.583). This receipt's hash covers every field on it, plus the hash of receipt 11094, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11095
    26 Oct 2026, 18:28 UTC

    VPS8

    dopamine neurons, braak

    predictionVPS8 in dopamine neurons tracks Braak Lewy-body stage

    registered67b1f456161b8ca1

    discovery-0.21 p=0.583 n=9

    replication+0.15 p=0.697 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.21, p 0.583)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    f3328174097adc938828227a…
    follows ef52f00fd2a3…

Covered by the on-chain checkpoint of receipt 11102 (2026-10-26 18:39 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11095: VPS8 in dopamine neurons, braak

power
full sample -0.01 (p 0.956, n 18), 95% CI -0.48 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
skeptic
leave-one-out range -0.17 to +0.12, sign flips 7; without severely affected donors -0.01 (p 0.956, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for VPS8 in dopamine neurons.

case closed: nothing better to follow up.