Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11023

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.20, p 0.599). This receipt's hash covers every field on it, plus the hash of receipt 11022, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11023
    26 Oct 2026, 16:50 UTC

    LILRB2

    microglia, braak

    predictionLILRB2 in microglia tracks Braak Lewy-body stage

    registered2725efe6a30143ab

    discovery+0.20 p=0.599 n=9

    replication-0.26 p=0.507 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.20, p 0.599)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    13c4cd66d87257068a5b5a03…
    follows 1fa8b4ad030c…

Covered by the on-chain checkpoint of receipt 11025 (2026-10-26 16:53 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11023: LILRB2 in microglia, braak

power
full sample +0.09 (p 0.709, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.08 (p 0.767, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic
leave-one-out range -0.04 to +0.25, sign flips 2; without severely affected donors +0.09 (p 0.709, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LILRB2 in microglia.

case closed: nothing better to follow up.