Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10970

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.65, p 0.060). This receipt's hash covers every field on it, plus the hash of receipt 10969, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10970
    26 Oct 2026, 15:33 UTC

    EFEMP2

    dopamine neurons, braak

    predictionEFEMP2 in dopamine neurons tracks Braak Lewy-body stage

    registered3db6d80fc8f29f10

    discovery-0.65 p=0.060 n=9

    replication-0.67 p=0.048 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.65, p 0.060)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6de85ba0606241d3665fbc87…
    follows 1504eb3c2ace…

Covered by the on-chain checkpoint of receipt 10974 (2026-10-26 15:38 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10970: EFEMP2 in dopamine neurons, braak

power
full sample -0.48 (p 0.043, n 18), 95% CI -0.77 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.45 (p 0.059, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.018, n 18). not the mix.
skeptic
leave-one-out range -0.56 to -0.40, sign flips 0; without severely affected donors -0.48 (p 0.043, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EFEMP2 in dopamine neurons.

case closed: nothing better to follow up.