Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10943

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.813). This receipt's hash covers every field on it, plus the hash of receipt 10942, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10943
    26 Oct 2026, 14:50 UTC

    MTG1

    dopamine neurons, braak

    predictionMTG1 in dopamine neurons tracks Braak Lewy-body stage

    registered416315993ee43cc3

    discovery-0.09 p=0.813 n=9

    replication-0.23 p=0.545 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.813)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d0bc93a89d9b6574d2adb89f…
    follows ec6a98e0922f…

Covered by the on-chain checkpoint of receipt 10945 (2026-10-26 14:53 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10943: MTG1 in dopamine neurons, braak

power
full sample -0.17 (p 0.498, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.17 (p 0.509, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.091, n 18). could be the mix.
skeptic
leave-one-out range -0.28 to -0.07, sign flips 0; without severely affected donors -0.17 (p 0.498, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MTG1 in dopamine neurons.

case closed: nothing better to follow up.