Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10886

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.50, p 0.173). This receipt's hash covers every field on it, plus the hash of receipt 10885, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10886
    26 Oct 2026, 13:33 UTC

    CHRND

    dopamine neurons, braak

    predictionCHRND in dopamine neurons tracks Braak Lewy-body stage

    registeredb46fb94e5ed675db

    discovery-0.50 p=0.173 n=9

    replication+0.18 p=0.639 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.50, p 0.173)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d17cb71a8cd85485e903df98…
    follows a31e97806d2b…

Covered by the on-chain checkpoint of receipt 10891 (2026-10-26 13:43 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10886: CHRND in dopamine neurons, braak

power
full sample -0.34 (p 0.161, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.148, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.039, n 18). not the mix.
skeptic
leave-one-out range -0.45 to -0.26, sign flips 0; without severely affected donors -0.34 (p 0.161, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CHRND in dopamine neurons.

case closed: nothing better to follow up.