Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10703

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.45, p 0.224). This receipt's hash covers every field on it, plus the hash of receipt 10702, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10703
    26 Oct 2026, 09:21 UTC

    IFIT3

    oligodendrocytes, braak

    predictionIFIT3 in oligodendrocytes tracks Braak Lewy-body stage

    registered4ad09c67408b04dd

    discovery+0.45 p=0.224 n=9

    replication+0.10 p=0.795 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.45, p 0.224)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    614ccc1d38c88d60760157e8…
    follows c9e8d7d4de04…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10703: IFIT3 in oligodendrocytes, braak

power
full sample +0.37 (p 0.135, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.33 (p 0.176, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.33 (p 0.176, n 18). could be the mix.
skeptic
leave-one-out range +0.29 to +0.47, sign flips 0; without severely affected donors +0.37 (p 0.135, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IFIT3 in oligodendrocytes.

case closed: nothing better to follow up.