Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10619

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.22, p 0.569). This receipt's hash covers every field on it, plus the hash of receipt 10618, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10619
    26 Oct 2026, 07:28 UTC

    SLC4A4

    astrocytes, braak

    predictionSLC4A4 in astrocytes tracks Braak Lewy-body stage

    registered8a2c67bebd57da98

    discovery-0.22 p=0.569 n=9

    replication+0.08 p=0.838 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.22, p 0.569)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    53fe5d7e5e83a4b7fe978c0a…
    follows 2851eecffbd9…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10619: SLC4A4 in astrocytes, braak

power
full sample +0.09 (p 0.735, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.14 (p 0.573, n 18). could be the mix.
skeptic
leave-one-out range -0.05 to +0.19, sign flips 3; without severely affected donors +0.09 (p 0.735, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC4A4 in astrocytes.

case closed: nothing better to follow up.