Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10598

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.07, p 0.852). This receipt's hash covers every field on it, plus the hash of receipt 10597, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10598
    26 Oct 2026, 07:00 UTC

    CAPN6

    dopamine neurons, braak

    predictionCAPN6 in dopamine neurons tracks Braak Lewy-body stage

    registered5b5db96fa271dbe3

    discovery+0.07 p=0.852 n=9

    replication+0.31 p=0.416 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.07, p 0.852)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    199aeab97bcd8cefc9e9af71…
    follows 898c7ee25726…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10598: CAPN6 in dopamine neurons, braak

power
full sample +0.24 (p 0.337, n 18), 95% CI -0.26 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.29 (p 0.235, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.185, n 18). could be the mix.
skeptic
leave-one-out range +0.13 to +0.33, sign flips 0; without severely affected donors +0.24 (p 0.337, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CAPN6 in dopamine neurons.

case closed: nothing better to follow up.