Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10473

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.37, p 0.334). This receipt's hash covers every field on it, plus the hash of receipt 10472, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10473
    26 Oct 2026, 04:13 UTC

    CYP17A1

    dopamine neurons, braak

    predictionCYP17A1 in dopamine neurons tracks Braak Lewy-body stage

    registeredfc977daa92726036

    discovery-0.37 p=0.334 n=9

    replication-0.07 p=0.859 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.37, p 0.334)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    48a9c21a28179ad6d0a220df…
    follows ca1e1e3204ca…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10473: CYP17A1 in dopamine neurons, braak

power
full sample -0.26 (p 0.302, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.28 (p 0.265, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.239, n 18). could be the mix.
skeptic
leave-one-out range -0.38 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.302, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYP17A1 in dopamine neurons.

case closed: nothing better to follow up.