Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1047

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.29, p 0.443). This receipt's hash covers every field on it, plus the hash of receipt 1046, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1047
    17 Oct 2026, 13:01 UTC

    CORO1C

    dopamine neurons, braak

    predictionCORO1C in dopamine neurons tracks Braak Lewy-body stage

    registered3a5e531decb7d90b

    discovery-0.29 p=0.443 n=9

    replication-0.07 p=0.851 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.29, p 0.443)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    419181a9b733483eb1d54bb7…
    follows f880769ddf9d…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1047: CORO1C in dopamine neurons, braak

power
full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.14 (p 0.567, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.781, n 18). could be the mix.
skeptic
leave-one-out range -0.30 to -0.07, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CORO1C in dopamine neurons.

case closed: nothing better to follow up.