Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1043

A sealed prediction that did not hold.

did not replicate (discovery +0.74 p 0.024; held-out -0.08 p 0.838). This receipt's hash covers every field on it, plus the hash of receipt 1042, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1043
    17 Oct 2026, 12:56 UTC

    INPP5F

    dopamine neurons, braak

    predictionINPP5F in dopamine neurons tracks Braak Lewy-body stage

    registeredd29a2c7254dcc589

    discovery+0.74 p=0.024 n=9

    replication-0.08 p=0.838 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery +0.74 p 0.024; held-out -0.08 p 0.838)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    c7af361d0afe4e9d99f26a5a…
    follows 611a06495228…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1043: INPP5F in dopamine neurons, braak

power
full sample +0.29 (p 0.235, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.45 (p 0.060, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.46 (p 0.055, n 18). could be the mix.
skeptic
leave-one-out range +0.22 to +0.44, sign flips 0; without severely affected donors +0.29 (p 0.235, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for INPP5F in dopamine neurons.

case closed: nothing better to follow up.