Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10405

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.39, p 0.300). This receipt's hash covers every field on it, plus the hash of receipt 10404, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10405
    26 Oct 2026, 02:44 UTC

    SLCO1B3

    dopamine neurons, braak

    predictionSLCO1B3 in dopamine neurons tracks Braak Lewy-body stage

    registered9752d233643eb6f0

    discovery-0.39 p=0.300 n=9

    replication-0.50 p=0.173 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.39, p 0.300)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5378bb4117465dfaac288ce0…
    follows 53bfa6b48e57…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10405: SLCO1B3 in dopamine neurons, braak

power
full sample -0.42 (p 0.080, n 18), 95% CI -0.74 to +0.05. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.45 (p 0.062, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.055, n 18). could be the mix.
skeptic
leave-one-out range -0.52 to -0.35, sign flips 0; without severely affected donors -0.42 (p 0.080, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLCO1B3 in dopamine neurons.

case closed: nothing better to follow up.