Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10403

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.10, p 0.790). This receipt's hash covers every field on it, plus the hash of receipt 10402, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10403
    26 Oct 2026, 02:42 UTC

    PCSK2

    dopamine neurons, braak

    predictionPCSK2 in dopamine neurons tracks Braak Lewy-body stage

    registeredb6948da1c035c4dd

    discovery+0.10 p=0.790 n=9

    replication+0.25 p=0.517 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.10, p 0.790)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c7f4be297e41c5e07214ce84…
    follows 0abd8ed1c7b3…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10403: PCSK2 in dopamine neurons, braak

power
full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
skeptic
leave-one-out range +0.08 to +0.31, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PCSK2 in dopamine neurons.

case closed: nothing better to follow up.