Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10275

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.25, p 0.517). This receipt's hash covers every field on it, plus the hash of receipt 10274, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10275
    26 Oct 2026, 00:37 UTC

    CHUK

    dopamine neurons, braak

    predictionCHUK in dopamine neurons tracks Braak Lewy-body stage

    registered7c8f90caa02e69cc

    discovery+0.25 p=0.517 n=9

    replication+0.01 p=0.982 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.25, p 0.517)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6025819cb3c7d5db2c26805d…
    follows d3994b927a19…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10275: CHUK in dopamine neurons, braak

power
full sample +0.19 (p 0.455, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.20 (p 0.429, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.20 (p 0.429, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.34, sign flips 0; without severely affected donors +0.19 (p 0.455, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CHUK in dopamine neurons.

case closed: nothing better to follow up.