Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10116

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.46, p 0.217). This receipt's hash covers every field on it, plus the hash of receipt 10115, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10116
    25 Oct 2026, 21:05 UTC

    CD2AP

    dopamine neurons, braak

    predictionCD2AP in dopamine neurons tracks Braak Lewy-body stage

    registered38af417718c615eb

    discovery+0.46 p=0.217 n=9

    replication+0.74 p=0.021 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.46, p 0.217)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a368d0675f2cc31d68ba63b5…
    follows 0d48d35d84ee…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10116: CD2AP in dopamine neurons, braak

power
full sample +0.54 (p 0.021, n 18), 95% CI +0.10 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.51 (p 0.031, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.027, n 18). not the mix.
skeptic
leave-one-out range +0.50 to +0.74, sign flips 0; without severely affected donors +0.54 (p 0.021, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CD2AP in dopamine neurons.

case closed: nothing better to follow up.