Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10063

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.64, p 0.063). This receipt's hash covers every field on it, plus the hash of receipt 10062, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10063
    25 Oct 2026, 19:54 UTC

    LY86

    microglia, braak

    predictionLY86 in microglia tracks Braak Lewy-body stage

    registeredd59ec31d3aa18c82

    discovery+0.64 p=0.063 n=9

    replication-0.08 p=0.842 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.64, p 0.063)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b2cebf6f54fa19a819ae7943…
    follows 4793df0d615a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10063: LY86 in microglia, braak

power
full sample +0.17 (p 0.504, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.20 (p 0.424, n 18). could be the mix.
skeptic
leave-one-out range +0.05 to +0.31, sign flips 0; without severely affected donors +0.17 (p 0.504, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for LY86 in microglia.

case closed: nothing better to follow up.